ROI Calculator for ALS Studies

ALS or Progressive Disease Protocols per Year ℹ️ The number of mouse studies your facility runs each year that target progressive diseases like ALS, where early detection of symptoms matters. This sets the pool of eligible protocols that could benefit from Envision monitoring. Envision Adoption Rate (0–1) ℹ️ This is the fraction of those protocols that are already using (or are expected to use) the Envision system. Example: If Envision is used in 3 of 10 ALS protocols, the adoption rate is 0.3. Confirmatory Study Avoidance Rate (0–1) ℹ️ What portion of Envision-equipped studies would normally require a follow-up confirmatory study—such as to verify disease onset—but can now avoid it thanks to earlier and clearer detection. Example: If 25% of protocols typically need a second run that is avoided, this value is 0.25. Group Size per Confirmatory Study (Animals) ℹ️ How many animals would be used in that avoided confirmatory study (usually both treatment and control groups combined). Example: A confirmatory cohort with 10 animals per group = 20 total.

Fuochi et al. (2023) – Retrospective Dataset Reuse

Reanalysis Opportunities per Year (Protocols) ℹ️ How many studies per year generate high-quality behavioral datasets that could potentially be reused for new questions or exploratory analysis. This is the base number of protocols where reuse could happen instead of running a brand-new cohort. Example: 5 longitudinal studies per year might have reusable data. Proportion Reused from Prior Data (0–1) ℹ️ What fraction of those studies actually lead to data reuse (i.e., a new study was avoided because analysts were able to extract needed insights from existing datasets). Example: If half of these cases lead to reuse instead of launching a new experiment, the value is 0.5. Animals Typically Used in Avoided Study ℹ️ The number of animals that would’ve been required in a typical study that was avoided by using past data instead. Example: Avoiding a new 2-arm behavior study that typically uses 12 animals per group = 24 total. Calculate